BIOCOMPATIBILITY INNOVATION

 LONG LIFE FOR BIOPROSTHETIC HEART VALVES 


COMPANY
IN HARMONY WITH LIFE

BioCompatibility Innovation (BCI) is a companyfounded in 2014 and regularly registered in theItalian National Register of Innovative Start-ups.BCI operates in the biomedical and biotechnologyfields and has focused mainly on the developmentof new technologies for the improvement of thebiocompatibility degree of biological implantablemedical devices and food from animal origins. Atthe BCI laboratories, all operation, developingtests, diagnostic processes, cell-based assays andexperimental model (in-vivo and in-vitro tests)

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Biocompatibility improvements of bioprosthetic tissues
FACTA NOT PROMISES

With particular reference to biological implantable biomedical devices,BCI has made its efforts in the field of bioprosthetic heart valvessubstitutes (BHVs). BCI designed and developed two patented processes forthe treatment of soft animal tissues currently used to BHVs manufacturewith the aim to increase their duration. The treatment called FACTA iseffective for the inactivation of a particular antigenic epitope: thealpha-Gal molecule. Such xenogeneic antigen resulted present in mammaliananimal tissues (except in humans and higher primates) and is responsiblefor the onset of dystrophic phenomena that affect the behaviour ofcommercially available BHVs, limiting their life to about 10/12 yearsfrom the implant thus obliging both surgeons to a repetitive replacementof the prosthesis and patients to an even burdensome surgery.